The influence of solvents upon the effectiveness of carcinogenic agents.

نویسندگان

  • L A STRAIT
  • M K HRENOFF
  • K B DeOME
چکیده

In considering the explanation of the recognized influence of the solvent upon the carcinogenic effectiveness of a dissolved carcinogen we have focussed our attention upon the physical factors which affect the availability of the carcinogen to the tissues in situ. An attempted formulation (see Discussion) of a possible mechanism of transfer from the solvent to the nearby affected tissue suggested that the relative solubility of a carcinogen in solvent and in serum might be of importance. Therefore, we have investigated the relative solubility distribution of benzpyrene in serum and in a number of lipoid solvents for which reliable animal data (8) on tumor incidence have been obtained.

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عنوان ژورنال:
  • Cancer research

دوره 8 5  شماره 

صفحات  -

تاریخ انتشار 1948